Recently, a research paper titled ABA signaling is involved in the regulation of BSK1 stability mediated by the UBP24-PUB25/26 module in Arabidopsiswas published by Professor Dai Shaojun's team from the School of Life Sciences in Cell Reports. The study reveals that in Arabidopsis, the E3 ubiquitin ligase PUB25/26 and the deubiquitinating enzyme UBP24 dynamically regulate the stability of the BSK1 protein, thereby mediating plant responses to ABA signaling.
The study used Arabidopsis as a model system and found that compared to the wild-type (Col-0), the bsk1-1 mutant exhibited heightened sensitivity to ABA treatment. It elucidated the molecular mechanism by which ABA signaling coordinates stress responses through the regulation of BSK1 stability, a key component of the brassinosteroid signaling pathway, and proposed a dynamic regulatory module centered on BSK1, termed the "UBP24-PUB25/26" module.
Dr. Li Yuanyuan, jointly trained by Shanghai Normal University (SHNU) and Northeast Forestry University, and Zhao Zhe, a master's student in the School of Life Sciences at Shanghai Normal University(SHNU), are the co-first authors of the paper, with Professor Dai Shaojun serving as the corresponding author. This research was supported by the National Natural Science Foundation of China and the Shanghai Engineering Research Center for Plant Germplasm Resources.
The paper can be accessed by clicking https://doi.org/10.1016/j.celrep.2026.11718 .
